Three years after the zombie virus has gutted the United States of America a team of everyday heroes must transport the only known survivor of the plague from New York to California, where the last functioning viral lab waits for his blood.
In a continuation of Full House (1987), D.J. Fuller is a mother of three young boys and is a recent widow. D.J.'s sister Stephanie, her best friend Kimmy and Kimmy's teenage daughter all move in to help raise her sons. The house is now a lot fuller.